The molecular biology of human herpesvirus-6 latency and telomere integration.
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ABSTRACT:
SUBMITTER: Arbuckle JH
PROVIDER: S-EPMC3130849 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
The molecular biology of human herpesvirus-6 latency and telomere integration.
Arbuckle Jesse H JH Medveczky Peter G PG
Microbes and infection 20110331 8-9
The genomes of herpesviruses establish latency as a circular episome. However, Human herpesvirus-6 (HHV-6) has been shown to specifically integrate into the telomeres of chromosomes during latency and vertically transmit through the germ-line. This review will focus on the telomere integration of HHV-6, the potential viral and cellular genes that mediate integration, and the clinical impact on the host. ...[more]
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