Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration.
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ABSTRACT:
SUBMITTER: Campbell A
PROVIDER: S-EPMC5479784 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration.
Campbell Andrew A Hogestyn Jessica M JM Folts Christopher J CJ Lopez Brittany B Pröschel Christoph C Mock David D Mayer-Pröschel Margot M
Scientific reports 20170621 1
Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destruction results in progressive loss of myelin. Viral infections have long been suspected to be involved in these processes but their specific role remains elusive. Here we describe a novel mechanism by which HHV-6A, a member of the human herpesvirus family, ma ...[more]
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