Ontology highlight
ABSTRACT:
SUBMITTER: Tang H
PROVIDER: S-EPMC3145206 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Tang Hua H Cao Weiping W Kasturi Sudhir Pai SP Ravindran Rajesh R Nakaya Helder I HI Kundu Kousik K Murthy Niren N Kepler Thomas B TB Malissen Bernard B Pulendran Bali B
Nature immunology 20100523 7
The mechanisms that initiate T helper type 2 (T(H)2) responses are poorly understood. Here we demonstrate that cysteine protease-induced T(H)2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4). Subcutaneous immunization with papain plus antigen induced reactive oxygen species (ROS) in lymph node DCs and in dermal DCs and epithelial cells of the skin. ROS orchestrated T(H)2 responses by inducing oxidized lipids that tr ...[more]