Evaluation of a new DNA test for detection of carcinogenic human papillomavirus.
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ABSTRACT:
SUBMITTER: Castle PE
PROVIDER: S-EPMC3147736 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Evaluation of a new DNA test for detection of carcinogenic human papillomavirus.
Castle Philip E PE Gutierrez Erin C EC Leitch Sharon V SV Maus Courtney E CE McMillian Ray A RA Nussbaumer William A WA Vaughan Laurence M LM Wheeler Cosette M CM Gravitt Patti E PE Schiffman Mark M
Journal of clinical microbiology 20110601 8
Using archived specimens, we evaluated a new automated real-time PCR assay (BD Diagnostics) that detects all carcinogenic human papillomaviruses (HPV) and provides HPV genotyping for seven of them, including HPV16 and HPV18, the two most carcinogenic HPV genotypes. We found comparable results with Hybrid Capture 2 (HC2) for detection of carcinogenic HPV (n = 473) and with Linear Array and Line Blot Assay (n = 371) for detection of individual HPV genotypes. ...[more]
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