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Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum.

ABSTRACT: Analysis of longitudinally obtained HIV-1 env sequences from an individual with reported cross-reactive neutralizing activity revealed that the majority of viral variants obtained from serum between 4 and 7 years after seroconversion were unable to persist in peripheral blood. Here we show that these viral variants were more sensitive to autologous serum neutralization, had shorter envelopes with fewer potential N-linked glycosylation sites, and showed lower replication kinetics than successfully evolving HIV-1 variants. These data reflect the host selection pressures on phenotypic characteristics of HIV-1 and illustrate in detail the dynamic interaction between HIV-1 and its host's humoral immune responses.

SUBMITTER: van Gils MJ

PROVIDER: S-EPMC3147988 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum.

van Gils Marit J MJ Edo-Matas Diana D Bowles Emma J EJ Burger Judith A JA Stewart-Jones Guillaume B GB Schuitemaker Hanneke H

Journal of virology 20110608 16

Analysis of longitudinally obtained HIV-1 env sequences from an individual with reported cross-reactive neutralizing activity revealed that the majority of viral variants obtained from serum between 4 and 7 years after seroconversion were unable to persist in peripheral blood. Here we show that these viral variants were more sensitive to autologous serum neutralization, had shorter envelopes with fewer potential N-linked glycosylation sites, and showed lower replication kinetics than successfull ...[more]

PMID: 21653664

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