Ontology highlight
ABSTRACT:
SUBMITTER: Roversi P
PROVIDER: S-EPMC3150940 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Roversi Pietro P Johnson Steven S Caesar Joseph J E JJ McLean Florence F Leath Kirstin J KJ Tsiftsoglou Stefanos A SA Morgan B Paul BP Harris Claire L CL Sim Robert B RB Lea Susan M SM
Proceedings of the National Academy of Sciences of the United States of America 20110718 31
The complement system is a key component of innate and adaptive immune responses. Complement regulation is critical for prevention and control of disease. We have determined the crystal structure of the complement regulatory enzyme human factor I (fI). FI is in a proteolytically inactive form, demonstrating that it circulates in a zymogen-like state despite being fully processed to the mature sequence. Mapping of functional data from mutants of fI onto the structure suggests that this inactive f ...[more]