Ontology highlight
ABSTRACT:
SUBMITTER: Wu Z
PROVIDER: S-EPMC3162971 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Wu Zaigui Z You Zeshan Z Zhang Cai C Li Zhuyu Z Su Xiumei X Zhang Xiuming X Li Yinguang Y
Clinical & developmental immunology 20110713
Unexplained recurrent spontaneous abortion (URSA) is an alloimmune disease associated with the failure of fetal-maternal immunologic tolerance in which the regulatory T lymphocytes (Treg) play a pivotal role. It is well known that Forkhead box P3 (Foxp3) is a crucial regulatory factor for the development and function of Treg cells. It has also been established that deficiency of the Foxp3 gene suppresses the regulatory function of Treg cells. To determine if functional polymorphisms at the Foxp3 ...[more]