Ontology highlight
ABSTRACT:
SUBMITTER: Azizi A
PROVIDER: S-EPMC7538155 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Azizi Afnan A Herrmann Anne A Wan Yinan Y Buse Salvador Jrp SJ Keller Philipp J PJ Goldstein Raymond E RE Harris William A WA
eLife 20201006
An important question in early neural development is the origin of stochastic nuclear movement between apical and basal surfaces of neuroepithelia during interkinetic nuclear migration. Tracking of nuclear subpopulations has shown evidence of diffusion - mean squared displacements growing linearly in time - and suggested crowding from cell division at the apical surface drives basalward motion. Yet, this hypothesis has not yet been tested, and the forces involved not quantified. We employ long-t ...[more]