Ontology highlight
ABSTRACT:
SUBMITTER: Yang YT
PROVIDER: S-EPMC3431462 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Yang Yu-Ting YT Wang Chia-Lin CL Van Aelst Linda L
Nature neuroscience 20120729 9
Neurogenesis in the developing neocortex relies on the ability of radial glial progenitor cells (RGCs) to switch from proliferative to differentiative neuron-generating divisions, but the molecular mechanisms that control this switch in a correct temporal manner are not well understood. Here, we show that DOCK7, a member of the DOCK180 family of proteins, regulates RGC proliferation versus differentiation. Silencing of DOCK7 in RGCs of developing mouse embryos impedes neuronal differentiation an ...[more]