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A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas.

ABSTRACT: Lithiation of N'-benzyl-N,N-dimethylurea and its substituted derivatives with t-BuLi (3.3 equiv) in anhydrous THF at 0 °C followed by reaction with various electrophiles afforded a range of 3-substituted isoindolin-1-ones in high yields.

SUBMITTER: Smith K

PROVIDER: S-EPMC3182431 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas.

Smith Keith K El-Hiti Gamal A GA Hegazy Amany S AS Kariuki Benson B

Beilstein journal of organic chemistry 20110906

Lithiation of N'-benzyl-N,N-dimethylurea and its substituted derivatives with t-BuLi (3.3 equiv) in anhydrous THF at 0 °C followed by reaction with various electrophiles afforded a range of 3-substituted isoindolin-1-ones in high yields. ...[more]

PMID: 21977206

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