Examining troughs in the mass distribution of all theoretically possible tryptic peptides.
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ABSTRACT:
SUBMITTER: Nefedov AV
PROVIDER: S-EPMC3184890 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Examining troughs in the mass distribution of all theoretically possible tryptic peptides.
Nefedov Alexey V AV Mitra Indranil I Brasier Allan R AR Sadygov Rovshan G RG
Journal of proteome research 20110809 9
This work describes the mass distribution of all theoretically possibly tryptic peptides made of 20 amino acids, up to the mass of 3 kDa, with resolution of 0.001 Da. We characterize regions between the peaks of the distribution, including gaps (forbidden zones) and low-populated areas (quiet zones). We show how the gaps shrink over the mass range and when they completely disappear. We demonstrate that peptide compositions in quiet zones are less diverse than those in the peaks of the distributi ...[more]
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