Ontology highlight
ABSTRACT:
SUBMITTER: Trausch JJ
PROVIDER: S-EPMC3196276 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Trausch Jeremiah J JJ Ceres Pablo P Reyes Francis E FE Batey Robert T RT
Structure (London, England : 1993) 20110908 10
Transport and biosynthesis of folate and its derivatives are frequently controlled by the tetrahydrofolate (THF) riboswitch in Firmicutes. We have solved the crystal structure of the THF riboswitch aptamer in complex with folinic acid, a THF analog. Uniquely, this structure reveals two molecules of folinic acid binding to a single structured domain. These two sites interact with ligand in a similar fashion, primarily through recognition of the reduced pterin moiety. 7-deazaguanine, a soluble ana ...[more]