Ontology highlight
ABSTRACT:
SUBMITTER: Vicens Q
PROVIDER: S-EPMC3201879 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Vicens Quentin Q Mondragón Estefanía E Batey Robert T RT
Nucleic acids research 20110710 19
Understanding the nature of the free state of riboswitch aptamers is important for illuminating common themes in gene regulation by riboswitches. Prior evidence indicated the flavin mononucleotide (FMN)-binding riboswitch aptamer adopted a 'bound-like' structure in absence of FMN, suggesting only local conformational changes upon ligand binding. In the scope of pinpointing the general nature of such changes at the nucleotide level, we performed SHAPE mapping experiments using the aptamer domain ...[more]