Ontology highlight
ABSTRACT:
SUBMITTER: Janas MM
PROVIDER: S-EPMC3197686 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Janas Maja M MM Khaled Mehdi M Schubert Steffen S Bernstein Jacob G JG Golan David D Veguilla Rosa A RA Fisher David E DE Shomron Noam N Levy Carmit C Novina Carl D CD
PLoS genetics 20111020 10
The majority of mammalian microRNA (miRNA) genes reside within introns of protein-encoding and non-coding genes, yet the mechanisms coordinating primary transcript processing into both mature miRNA and spliced mRNA are poorly understood. Analysis of melanoma invasion suppressor miR-211 expressed from intron 6 of melastatin revealed that microprocessing of miR-211 promotes splicing of the exon 6-exon 7 junction of melastatin by a mechanism requiring the RNase III activity of Drosha. Additionally, ...[more]