Ontology highlight
ABSTRACT:
SUBMITTER: Asangani IA
PROVIDER: S-EPMC3663613 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Asangani Irfan A IA Harms Paul W PW Dodson Lois L Pandhi Mithil M Kunju Lakshmi P LP Maher Christopher A CA Fullen Douglas R DR Johnson Timothy M TM Giordano Thomas J TJ Palanisamy Nallasivam N Chinnaiyan Arul M AM
Oncotarget 20120901 9
MicroRNAs (miRs) play a key role in cancer etiology by coordinately repressing numerous target genes involved in cell proliferation, migration and invasion. The genomic region in chromosome 9p21 that encompasses miR-31 is frequently deleted in solid cancers including melanoma; however the expression and functional role of miR-31 has not been previously studied in melanoma. Here, we queried the expression status and performed functional characterization of miR-31 in melanoma tissues and cell line ...[more]