Ontology highlight
ABSTRACT:
SUBMITTER: Xia Z
PROVIDER: S-EPMC3199358 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Xia Zuyong Z Xing Yun Y Jeon Jongho J Kim Young-Pil YP Gall Jessica J Dragulescu-Andrasi Anca A Gambhir Sanjiv S SS Rao Jianghong J
ACS chemical biology 20110823 10
We report here an immobilization strategy using a collagen binding protein to deliver and confine synthetic reporters to the extracellular microenvironment in vivo for noninvasively imaging the activity of targets in the microenvironment. We show that the immobilization of reporters on collagens in the local microenvironment is highly efficient and physiologically stable for repetitive, long-term imaging. By using this strategy we successfully developed an immobilized bioluminescent activatable ...[more]