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Total synthesis of (±)-dragmacidin E.

ABSTRACT: The bis indole sponge alkaloid dragmacidin E was synthesized in racemic form over 25 steps starting from 7-benzhydroxyindole. Key steps include (a) a Witkop cyclization to facilitate construction of the indole-spanning seven-membered ring and (b) a cyclodehydrative pyrazinone synthesis that unites the two indole-containing sectors.

SUBMITTER: Feldman KS

PROVIDER: S-EPMC3200574 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Total synthesis of (±)-dragmacidin E.

Feldman Ken S KS Ngernmeesri Paiboon P

Organic letters 20110929 20

The bis indole sponge alkaloid dragmacidin E was synthesized in racemic form over 25 steps starting from 7-benzhydroxyindole. Key steps include (a) a Witkop cyclization to facilitate construction of the indole-spanning seven-membered ring and (b) a cyclodehydrative pyrazinone synthesis that unites the two indole-containing sectors. ...[more]

PMID: 21958431

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