Ontology highlight
ABSTRACT:
SUBMITTER: Johnson JL
PROVIDER: S-EPMC3203208 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Johnson Jodi L JL Lowell Brian C BC Ryabinina Olga P OP Lloyd R Stephen RS McCullough Amanda K AK
The Journal of investigative dermatology 20101007 3
UV light causes DNA damage in skin cells, leading to more than one million cases of non-melanoma skin cancer diagnosed annually in the United States. Although human cells possess a mechanism (nucleotide excision repair) to repair UV-induced DNA damage, mutagenesis still occurs when DNA is replicated before repair of these photoproducts. Although human cells have all the enzymes necessary to complete an alternate repair pathway, base excision repair (BER), they lack a DNA glycosylase that can ini ...[more]