Ontology highlight
ABSTRACT:
SUBMITTER: Roberts SA
PROVIDER: S-EPMC6571124 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Roberts Steven A SA Brown Alexander J AJ Wyrick John J JJ
BioEssays : news and reviews in molecular, cellular and developmental biology 20190225 3
Somatic mutations arising in human skin cancers are heterogeneously distributed across the genome, meaning that certain genomic regions (e.g., heterochromatin or transcription factor binding sites) have much higher mutation densities than others. Regional variations in mutation rates are typically not a consequence of selection, as the vast majority of somatic mutations in skin cancers are passenger mutations that do not promote cell growth or transformation. Instead, variations in DNA repair ac ...[more]