Ontology highlight
ABSTRACT:
SUBMITTER: Baker TA
PROVIDER: S-EPMC3209554 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Baker Tania A TA Sauer Robert T RT
Biochimica et biophysica acta 20110627 1
ClpXP is a AAA+ protease that uses the energy of ATP binding and hydrolysis to perform mechanical work during targeted protein degradation within cells. ClpXP consists of hexamers of a AAA+ ATPase (ClpX) and a tetradecameric peptidase (ClpP). Asymmetric ClpX hexamers bind unstructured peptide tags in protein substrates, unfold stable tertiary structure in the substrate, and then translocate the unfolded polypeptide chain into an internal proteolytic compartment in ClpP. Here, we review our prese ...[more]