Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC4178486 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Li Linfeng L Abraham Adedoyin D AD Zhou Qiong Q Ali Hadi H O'Brien Jeremy V JV Hamill Brayden D BD Arcaroli John J JJ Messersmith Wells A WA LaBarbera Daniel V DV
Marine drugs 20140919 9
Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a therapeutic agent has been access to sufficient amounts of material for biological testing. Although there are two reported syntheses of neo, both require 12 steps with low overall yields (≤6%). In this article, we report an improved total synthesi ...[more]