Ontology highlight
ABSTRACT:
SUBMITTER: Elliott KS
PROVIDER: S-EPMC3664369 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Elliott Katherine S KS Chapman Kay K Day-Williams Aaron A Panoutsopoulou Kalliope K Southam Lorraine L Lindgren Cecilia M CM Arden Nigel N Aslam Nadim N Birrell Fraser F Carluke Ian I Carr Andrew A Deloukas Panos P Doherty Michael M Loughlin John J McCaskie Andrew A Ollier William E R WE Rai Ashok A Ralston Stuart S Reed Mike R MR Spector Timothy D TD Valdes Ana M AM Wallis Gillian A GA Wilkinson Mark M Zeggini Eleftheria E
Annals of the rheumatic diseases 20120906 6
<h4>Objectives</h4>Obesity as measured by body mass index (BMI) is one of the major risk factors for osteoarthritis. In addition, genetic overlap has been reported between osteoarthritis and normal adult height variation. We investigated whether this relationship is due to a shared genetic aetiology on a genome-wide scale.<h4>Methods</h4>We compared genetic association summary statistics (effect size, p value) for BMI and height from the GIANT consortium genome-wide association study (GWAS) with ...[more]