Ontology highlight
ABSTRACT:
SUBMITTER: Moore GL
PROVIDER: S-EPMC3242841 | biostudies-literature | 2011 Nov-Dec
REPOSITORIES: biostudies-literature
Moore Gregory L GL Bautista Cristina C Pong Erik E Nguyen Duc-Hanh T DH Jacinto Jonathan J Eivazi Araz A Muchhal Umesh S US Karki Sher S Chu Seung Y SY Lazar Greg A GA
mAbs 20111101 6
Bispecific antibodies based on full-length antibody structures are more optimal than fragment-based formats because they benefit from the favorable properties of the Fc region. However, the homodimeric nature of Fc effectively imposes bivalent binding on all current full-length bispecific antibodies, an attribute that can result in nonspecific activation of cross-linked receptors. We engineered a novel bispecific format, referred to as mAb-Fv, that utilizes a heterodimeric Fc region to enable mo ...[more]