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Synthesis of symmetrical and unsymmetrical pyrazines.

ABSTRACT: Opening of representative epoxides with 1,2-amino alcohols delivered the amino diols. The product amino diols were then oxidized under Swern conditions. The amino diketones so prepared were not isolated, but were condensed directly with hydroxylamine to give the substituted pyrazines.

SUBMITTER: Taber DF

PROVIDER: S-EPMC3251312 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature

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Synthesis of symmetrical and unsymmetrical pyrazines.

Taber Douglass F DF DeMatteo Peter W PW Taluskie Karen V KV

The Journal of organic chemistry 20070124 4

Opening of representative epoxides with 1,2-amino alcohols delivered the amino diols. The product amino diols were then oxidized under Swern conditions. The amino diketones so prepared were not isolated, but were condensed directly with hydroxylamine to give the substituted pyrazines. ...[more]

PMID: 17249730

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