Ontology highlight
ABSTRACT:
SUBMITTER: Knouf EC
PROVIDER: S-EPMC3258134 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Knouf Emily C EC Garg Kavita K Arroyo Jason D JD Correa Yesenia Y Sarkar Deepayan D Parkin Rachael K RK Wurz Kaitlyn K O'Briant Kathy C KC Godwin Andrew K AK Urban Nicole D ND Ruzzo Walter L WL Gentleman Robert R Drescher Charles W CW Swisher Elizabeth M EM Tewari Muneesh M
Nucleic acids research 20110914 2
Although microRNAs (miRNAs) are important regulators of gene expression, the transcriptional regulation of miRNAs themselves is not well understood. We employed an integrative computational pipeline to dissect the transcription factors (TFs) responsible for altered miRNA expression in ovarian carcinoma. Using experimental data and computational predictions to define miRNA promoters across the human genome, we identified TFs with binding sites significantly overrepresented among miRNA genes overe ...[more]