Ontology highlight
ABSTRACT:
SUBMITTER: Kato H
PROVIDER: S-EPMC3263505 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Cell death and differentiation 20110722 2
Mammalian target of rapamycin (mTOR) has a key role in the regulation of an array of cellular function. We found that rapamycin, an inhibitor of mTOR complex 1 (mTORC1), attenuated endoplasmic reticulum (ER) stress-induced apoptosis. Among three major branches of the unfolded protein response, rapamycin selectively suppressed the IRE1-JNK signaling without affecting PERK and ATF6 pathways. ER stress rapidly induced activation of mTORC1, which was responsible for induction of the IRE1-JNK pathway ...[more]