Ontology highlight
ABSTRACT:
SUBMITTER: Devine MJ
PROVIDER: S-EPMC3265381 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Devine Michael J MJ Ryten Mina M Vodicka Petr P Thomson Alison J AJ Burdon Tom T Houlden Henry H Cavaleri Fatima F Nagano Masumi M Drummond Nicola J NJ Taanman Jan-Willem JW Schapira Anthony H AH Gwinn Katrina K Hardy John J Lewis Patrick A PA Kunath Tilo T
Nature communications 20110823
A major barrier to research on Parkinson's disease is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells from patients and differentiate them into neurons affected by disease. Triplication of SNCA, encoding α-synuclein, causes a fully penetrant, aggressive form of Parkinson's disease with dementia. α-Synuclein dysfunction is the critical pathogenic event in Parkinson's disease, multiple system atrophy and dementia with Lewy bodies. Here we prod ...[more]