Ontology highlight
ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC5686106 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Wu Yu Y Pons Valérie V Goudet Amélie A Panigai Laetitia L Fischer Annette A Herweg Jo-Ana JA Kali Sabrina S Davey Robert A RA Laporte Jérôme J Bouclier Céline C Yousfi Rahima R Aubenque Céline C Merer Goulven G Gobbo Emilie E Lopez Roman R Gillet Cynthia C Cojean Sandrine S Popoff Michel R MR Clayette Pascal P Le Grand Roger R Boulogne Claire C Tordo Noël N Lemichez Emmanuel E Loiseau Philippe M PM Rudel Thomas T Sauvaire Didier D Cintrat Jean-Christophe JC Gillet Daniel D Barbier Julien J
Scientific reports 20171114 1
Intracellular pathogenic microorganisms and toxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host nutrition for their development. A potential approach to treat multiple pathogen infections and that should not induce drug resistance is the use of small molecules that target host components. We identified the compound 1-adamantyl (5-bromo-2-methoxybenzyl) amine (ABMA) from a cell-based high throughput screening for its capacity to protect human cells ...[more]