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Synthesis of benzisoxazolines by the coupling of arynes with nitrones.

ABSTRACT: A variety of substituted benzisoxazolines have been synthesized by the [3 + 2] cycloaddition of nitrones and arynes. The reaction scope is broad, the reaction conditions are mild, and the process tolerates a variety of functional groups.

SUBMITTER: Lu C

PROVIDER: S-EPMC3293248 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Synthesis of benzisoxazolines by the coupling of arynes with nitrones.

Lu Chun C Dubrovskiy Anton V AV Larock Richard C RC

The Journal of organic chemistry 20120216 5

A variety of substituted benzisoxazolines have been synthesized by the [3 + 2] cycloaddition of nitrones and arynes. The reaction scope is broad, the reaction conditions are mild, and the process tolerates a variety of functional groups. ...[more]

PMID: 22329405

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