Ontology highlight
ABSTRACT:
SUBMITTER: Samways DS
PROVIDER: S-EPMC3293559 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20120104 10
Human P2X receptors are a family of seven ATP-gated ion channels that transport Na(+), K(+), and Ca(2+) across cell surface membranes. The P2X4 receptor is unique among family members in its sensitivity to the macrocyclic lactone, ivermectin, which allosterically modulates both ion conduction and channel gating. In this paper we show that removing the fixed negative charge of a single acidic amino acid (Glu(51)) in the lateral entrance to the transmembrane pore markedly attenuates the effect of ...[more]