Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC3297197 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Yang Liuqing L Lin Chunru C Liu Wen W Zhang Jie J Ohgi Kenneth A KA Grinstein Jonathan D JD Dorrestein Pieter C PC Rosenfeld Michael G MG
Cell 20111101 4
Although eukaryotic nuclei contain distinct architectural structures associated with noncoding RNAs (ncRNAs), their potential relationship to regulated transcriptional programs remains poorly understood. Here, we report that methylation/demethylation of Polycomb 2 protein (Pc2) controls relocation of growth-control genes between Polycomb bodies (PcGs) and interchromatin granules (ICGs) in response to growth signals. This movement is the consequence of binding of methylated and unmethylated Pc2 t ...[more]