Ontology highlight
ABSTRACT:
SUBMITTER: Komori HK
PROVIDER: S-EPMC3311739 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Komori H Kiyomi HK Witherden Deborah A DA Kelly Ryan R Sendaydiego Kevin K Jameson Julie M JM Teyton Luc L Havran Wendy L WL
Journal of immunology (Baltimore, Md. : 1950) 20120305 7
TCR-specific activation is pivotal to dendritic epidermal T cell (DETC) function during cutaneous wound repair. However, DETC TCR ligands are uncharacterized, and little is known about their expression patterns and kinetics. Using soluble DETC TCR tetramers, we demonstrate that DETC TCR ligands are not constitutively expressed in healthy tissue but are rapidly upregulated following wounding on keratinocytes bordering wound edges. Ligand expression is tightly regulated, with downmodulation follow ...[more]