Ontology highlight
ABSTRACT:
SUBMITTER: Moqtaderi Z
PROVIDER: S-EPMC3350333 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20100425 5
Genome-wide occupancy profiles of five components of the RNA polymerase III (Pol III) machinery in human cells identified the expected tRNA and noncoding RNA targets and revealed many additional Pol III-associated loci, mostly near short interspersed elements (SINEs). Several genes are targets of an alternative transcription factor IIIB (TFIIIB) containing Brf2 instead of Brf1 and have extremely low levels of TFIIIC. Strikingly, expressed Pol III genes, unlike nonexpressed Pol III genes, are sit ...[more]