Zn-mediated, Pd-catalyzed cross-couplings in water at room temperature without prior formation of organozinc reagents.

ABSTRACT: Mix in water, stir. That is all that is required in this new approach to sp(3)-sp(2) cross-couplings between an alkyl iodide and an aryl bromide, both potentially bearing functionality. They react under catalysis by Pd(0) in the presence of zinc powder, aided by a nonionic amphiphile, to give the alkylated aromatic. No organic solvents and no heating; just add water.

SUBMITTER: Krasovskiy A 

PROVIDER: S-EPMC3359135 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature