Ontology highlight
ABSTRACT:
SUBMITTER: Diao T
PROVIDER: S-EPMC3370690 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Chemical science 20111031
The direct α, β-dehydrogenation of aldehydes and ketones represents an efficient alternative to stepwise methods to prepare enal and enone products. Here, we describe a new Pd(TFA)(2)/4,5-diazafluorenone dehydrogenation catalyst that overcomes key limitations of previous catalyst systems. The scope includes successful reactivity with pharmaceutically important cyclopentanone and flavanone substrates, as well as acyclic ketones. Preliminary mechanistic studies compare the reactivity of this catal ...[more]