Ontology highlight
ABSTRACT:
SUBMITTER: Kuryavyi V
PROVIDER: S-EPMC3381514 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Kuryavyi Vitaly V Patel Dinshaw J DJ
Structure (London, England : 1993) 20100101 1
We report on the solution structure of an unprecedented intramolecular G-quadruplex formed by the guanosine-rich human chl1 intronic d(G(3)-N-G(4)-N(2)-G(4)-N-G(3)-N) 19-mer sequence in K(+)-containing solution. This G-quadruplex, composed of three stacked G-tetrads containing four syn guanines, represents a new folding topology with two unique conformational features. The first guanosine is positioned within the central G-tetrad, in contrast to all previous structures of unimolecular G-quadrupl ...[more]