Ontology highlight
ABSTRACT:
SUBMITTER: Place RF
PROVIDER: S-EPMC3381590 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Place Robert F RF Wang Ji J Noonan Emily J EJ Meyers Rachel R Manoharan Muthiah M Charisse Klaus K Duncan Rick R Huang Vera V Wang Xiaoling X Li Long-Cheng LC
Molecular therapy. Nucleic acids 20120327
Application of RNA interference (RNAi) in the clinic has improved with the development of novel delivery reagents (e.g., lipidoids). Although RNAi promises a therapeutic approach at silencing gene expression, practical methods for enhancing gene production still remain a challenge. Previously, we reported that double-stranded RNA (dsRNA) can activate gene expression by targeting promoter sequence in a phenomenon termed RNA activation (RNAa). In the present study, we investigate the therapeutic p ...[more]