Ontology highlight
ABSTRACT:
SUBMITTER: Mallet F
PROVIDER: S-EPMC341840 | biostudies-literature | 2004 Feb
REPOSITORIES: biostudies-literature
Mallet François F Bouton Olivier O Prudhomme Sarah S Cheynet Valérie V Oriol Guy G Bonnaud Bertrand B Lucotte Gérard G Duret Laurent L Mandrand Bernard B
Proceedings of the National Academy of Sciences of the United States of America 20040202 6
The definitive demonstration of a role for a recently acquired gene is a difficult task, requiring exhaustive genetic investigations and functional analysis. The situation is indeed much more complicated when facing multicopy gene families, because most or portions of the gene are conserved among the hundred copies of the family. This is the case for the ERVWE1 locus of the human endogenous retrovirus W family (HERV-W), which encodes an envelope glycoprotein (syncytin) likely involved in trophob ...[more]