Ontology highlight
ABSTRACT:
SUBMITTER: Momotani K
PROVIDER: S-EPMC3472095 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Trends in cardiovascular medicine 20120701 5
In normal and diseased vascular smooth muscle (SM), the RhoA pathway, which is activated by multiple agonists through G protein-coupled receptors (GPCRs), plays a central role in regulating basal tone and peripheral resistance. Multiple RhoA GTP exchange factors (GEFs) are expressed in SM, raising the possibility that specific agonists coupled to specific GPCRs may couple to distinct RhoGEFs and provide novel therapeutic targets. This review focuses on the function and mechanisms of activation o ...[more]