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Briacavatolides D-F, new briaranes from the Taiwanese octocoral Briareum excavatum.

ABSTRACT: In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D-F (1-3) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-3 and their cytotoxicity against selected cancer cell lines were evaluated.

SUBMITTER: Wang SK

PROVIDER: S-EPMC3475276 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Briacavatolides D-F, new briaranes from the Taiwanese octocoral Briareum excavatum.

Wang Shang-Kwei SK Yeh Tsun-Tai TT Duh Chang-Yih CY

Marine drugs 20120924 9

In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D-F (1-3) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-3 and their cytotoxicity against selected cancer cell lines were evaluated. ...[more]

PMID: 23118724

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