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Briarenols Q-T: Briaranes from A Cultured Octocoral Briareum stechei (Kukenthal, 1908).

ABSTRACT: Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q-T (1-4). The structures of new metabolites 1-4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS).

SUBMITTER: Zhang YL

PROVIDER: S-EPMC7460508 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Briarenols Q-T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908).

Zhang Yi-Lin YL Chiang Chih-Chao CC Lee Yi-Ting YT Wen Zhi-Hong ZH Wu Yang-Chang YC Wu Yu-Jen YJ Hwang Tsong-Long TL Wu Tung-Ying TY Chang Chia-Yuan CY Sung Ping-Jyun PJ

Marine drugs 20200724 8

Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q-T (1-4). The structures of new metabolites 1-4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS). ...[more]

PMID: 32722176

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