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Briarenols I-K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae).

ABSTRACT: Five 8,17-epoxybriaranes, including three new compounds-briarenols I-K (1-3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7.

SUBMITTER: Huynh TH

PROVIDER: S-EPMC7144368 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Briarenols I-K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae).

Huynh Thanh-Hao TH Fang Lee-Shing LS Chen Yu-Hsin YH Peng Bo-Rong BR Chen You-Ying YY Zheng Li-Guo LG Wu Yu-Jen YJ Wen Zhi-Hong ZH Chen Jih-Jung JJ Lin Tzu-Chi TC Sung Ping-Jyun PJ

Molecules (Basel, Switzerland) 20200319 6

Five 8,17-epoxybriaranes, including three new compounds-briarenols I-K (1-3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) r ...[more]

PMID: 32204524

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