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Briarenols C-E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum.

ABSTRACT: Three new polyoxygenated briarane diterpenoids, briarenols C-E (1-3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC₅₀ value of 4.65 ?M. Briarenol E (3) was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in a murine macrophage-like cell line, RAW 264.7, stimulated with lipopolysaccharides (LPS).

SUBMITTER: Chen NF

PROVIDER: S-EPMC6155408 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Briarenols C-E, New Polyoxygenated Briaranes from the Octocoral Briareum excavatum.

Chen Nan-Fu NF Su Yin-Di YD Hwang Tsong-Long TL Liao Zuo-Jian ZJ Tsui Kuan-Hao KH Wen Zhi-Hong ZH Wu Yang-Chang YC Sung Ping-Jyun PJ

Molecules (Basel, Switzerland) 20170317 3

Three new polyoxygenated briarane diterpenoids, briarenols C-E (1-3), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by interpretation of spectroscopic data, and the methylenecyclohexane ring in 1 was found to exist in a twisted boat conformation. Briarenol D (2) displayed an inhibitory effect on the release of elastase by human neutrophils with an IC50 value of 4.65 μM. Briarenol E ...[more]

PMID: 28304345

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