Ontology highlight
ABSTRACT:
SUBMITTER: Rorsman P
PROVIDER: S-EPMC5866358 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Physiological reviews 20180101 1
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only hormone capable of lowering the blood glucose concentration. Impaired insulin secretion results in the chronic hyperglycemia that characterizes type 2 diabetes (T2DM), which currently afflicts >450 million people worldwide. The healthy β-cell acts as a glucose sensor matching its output to the circulating glucose concentration. It does so via metabolically induced changes in electrical activity, which cu ...[more]