Ontology highlight
ABSTRACT:
SUBMITTER: Antony AN
PROVIDER: S-EPMC4786880 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Antony Anil Noronha AN Paillard Melanie M Moffat Cynthia C Juskeviciute Egle E Correnti Jason J Bolon Brad B Rubin Emanuel E Csordás György G Seifert Erin L EL Hoek Jan B JB Hajnóczky György G
Nature communications 20160309
Mitochondrial Ca(2+) uptake through the recently discovered Mitochondrial Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1). However, the physiological and pathological role of MICU1 remains unclear. Here we show that MICU1 is vital for adaptation to postnatal life and for tissue repair after injury. MICU1 knockout is perinatally lethal in mice without causing gross anatomical defects. We used liver regeneration after partial hepatectomy as a physiolo ...[more]