Ontology highlight
ABSTRACT:
SUBMITTER: Waldeck-Weiermair M
PROVIDER: S-EPMC4615007 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Waldeck-Weiermair Markus M Malli Roland R Parichatikanond Warisara W Gottschalk Benjamin B Madreiter-Sokolowski Corina T CT Klec Christiane C Rost Rene R Graier Wolfgang F WF
Scientific reports 20151022
Mitochondrial Ca(2+) uptake is a vital process that controls distinct cell and organelle functions. Mitochondrial calcium uptake 1 (MICU1) was identified as key regulator of the mitochondrial Ca(2+) uniporter (MCU) that together with the essential MCU regulator (EMRE) forms the mitochondrial Ca(2+) channel. However, mechanisms by which MICU1 controls MCU/EMRE activity to tune mitochondrial Ca(2+) signals remain ambiguous. Here we established a live-cell FRET approach and demonstrate that elevati ...[more]