Ontology highlight
ABSTRACT:
SUBMITTER: Fujishima K
PROVIDER: S-EPMC3491647 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Fujishima Kazuto K Horie Ryota R Mochizuki Atsushi A Kengaku Mineko M
Development (Cambridge, England) 20120901 18
Neurons develop dendritic arbors in cell type-specific patterns. Using growing Purkinje cells in culture as a model, we performed a long-term time-lapse observation of dendrite branch dynamics to understand the rules that govern the characteristic space-filling dendrites. We found that dendrite architecture was sculpted by a combination of reproducible dynamic processes, including constant tip elongation, stochastic terminal branching, and retraction triggered by contacts between growing dendrit ...[more]