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Copper-catalyzed ortho-acylation of phenols with aryl aldehydes and its application in one-step preparation of xanthones.

ABSTRACT: In the presence of triphenylphosphine, copper(II) chloride can catalyze an intermolecular ortho-acylation reaction of phenols with aryl aldehydes. The reaction proceeds smoothly with a wide range of starting materials, and furthermore, it can be used to synthesize xanthone derivatives in a single step in high yields.

SUBMITTER: Hu J

PROVIDER: S-EPMC3496182 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Copper-catalyzed ortho-acylation of phenols with aryl aldehydes and its application in one-step preparation of xanthones.

Hu Jun J Adogla Enoch A EA Ju Yong Y Fan Daping D Wang Qian Q

Chemical communications (Cambridge, England) 20121015 91

In the presence of triphenylphosphine, copper(II) chloride can catalyze an intermolecular ortho-acylation reaction of phenols with aryl aldehydes. The reaction proceeds smoothly with a wide range of starting materials, and furthermore, it can be used to synthesize xanthone derivatives in a single step in high yields. ...[more]

PMID: 23069775

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