Ontology highlight
ABSTRACT:
SUBMITTER: Monini P
PROVIDER: S-EPMC3496724 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Monini Paolo P Cafaro Aurelio A Srivastava Indresh K IK Moretti Sonia S Sharma Victoria A VA Andreini Claudia C Chiozzini Chiara C Ferrantelli Flavia F Cossut Maria R Pavone MR Tripiciano Antonella A Nappi Filomena F Longo Olimpia O Bellino Stefania S Picconi Orietta O Fanales-Belasio Emanuele E Borsetti Alessandra A Toschi Elena E Schiavoni Ilaria I Bacigalupo Ilaria I Kan Elaine E Sernicola Leonardo L Maggiorella Maria T MT Montin Katy K Porcu Marco M Leone Patrizia P Leone Pasqualina P Collacchi Barbara B Palladino Clelia C Ridolfi Barbara B Falchi Mario M Macchia Iole I Ulmer Jeffrey B JB Buttò Stefano S Sgadari Cecilia C Magnani Mauro M Federico Maurizio P M MP Titti Fausto F Banci Lucia L Dallocchio Franco F Rappuoli Rino R Ensoli Fabrizio F Barnett Susan W SW Garaci Enrico E Ensoli Barbara B
PloS one 20121113 11
Use of Env in HIV vaccine development has been disappointing. Here we show that, in the presence of a biologically active Tat subunit vaccine, a trimeric Env protein prevents in monkeys virus spread from the portal of entry to regional lymph nodes. This appears to be due to specific interactions between Tat and Env spikes that form a novel virus entry complex favoring R5 or X4 virus entry and productive infection of dendritic cells (DCs) via an integrin-mediated pathway. These Tat effects do not ...[more]