Ontology highlight
ABSTRACT:
SUBMITTER: Gartner JJ
PROVIDER: S-EPMC3500261 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Gartner Jared J JJ Davis Sean S Wei Xiaomu X Lin Jimmy C JC Trivedi Niraj S NS Teer Jamie K JK Meltzer Paul S PS Rosenberg Steven A SA Samuels Yardena Y
BMC genomics 20120924
<h4>Background</h4>Metastasis is characterized by spreading of neoplastic cells to an organ other than where they originated and is the predominant cause of death among cancer patients. This holds true for melanoma, whose incidence is increasing more rapidly than any other cancer and once disseminated has few therapeutic options. Here we performed whole exome sequencing of two sets of matched normal and metastatic tumor DNAs.<h4>Results</h4>Using stringent criteria, we evaluated the similarities ...[more]